Universidad de Extremadura. Facultad de Enfermería y Terapia Ocupacional, Cáceres
Neuroprotective properties of queen bee acid by autophagy induction2021Martínez-Chacón G; Paredes-Baquero M; SMS Yakhine Diop; Uribe-Carretero E; Bargiela A; Sabater-Arcis M; Morales-Garcia J; Alarcón Gil J; Alegre-Cortés E; Canales-Cortés S; Rodríguez-Arribas M; Camello J; Bravo-San Pedro JM; Pérez-Castillo A; Artero R; González-Polo RA; Fuentes JM; Niso-Santano MCell Biol Toxicol The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress2021Yakhine-Diop SMS, Rodríguez-Arribas M, Canales-Cortés S, Martínez-Chacón G, Uribe-Carretero E, Blanco-Benítez M, Duque-González G, Paredes-Barquero M, Alegre-Cortés E, Climent V, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, Fuentes JM, González-Polo RA.Cell Biol Toxicol https://pubmed.ncbi.nlm.nih.gov/34060004/The dual role of necrostatin-1 in Parkinson's disease models2021Alegre-Cortes E, Martínez-Chacón G, Fuentes JM, Yakhine-Diop SMS.Neural Regen Res 16(10):2019-2020. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)2021Klionsky DJ….Fuentes JM…..Gonzalez-Polo RA….Niso-Santano M….Yakhine-Diop SMS…Uribe-Carretero E…..Tong CK.Autophagy 17(1):1-382 Metabolic alterations in plasma from patients with familial and idiopathic Parkinson's disease2020Yakhine-Diop SMS, Morales-García JA, Niso-Santano M, González-Polo RA, Uribe-Carretero E, Martinez-Chacon G, Durand S, Maiuri MC, Aiastui A, Zulaica M, Ruíz-Martínez J, López de Munain A, Pérez-Tur J, Pérez-Castillo A, Kroemer G, Bravo-San Pedro JM, Fuentes JM.Aging (Albany NY) ;12(17):16690-16708 Toxicity of Necrostatin-1 in Parkinson's Disease Models.2020Alegre-Cortés E, Muriel-González A, Canales-Cortés S, Uribe-Carretero E, Martínez-Chacón G, Aiastui A, López de Munain A, Niso-Santano M, Gonzalez-Polo RA, Fuentes JM, Yakhine-Diop SMSAntioxidants (Basel) 9(6):524. Autophagy modulation in animal models of corneal diseases: a systematic review2020Martínez-Chacón G, Vela FJ, Campos JL, Abellán E, Yakhine-Diop SMS, Ballestín A.Mol Cell Biochem 474(1-2):41-55 Natural Products in the Promotion of Healthspan and Longevity2019Niso-Santano M, González-Polo RA, Paredes-Barquero M, Fuentes JM, Aschner M.Clin Pharmacol Transl Med 3(1):149-151. Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack2019Martinez-Arroyo O, Gruevska A, Victor VM, González-Polo RA, Yakhine-Diop SMS, Fuentes JM, Esplugues JV, Blas-Garcia A, Apostolova N.Antiviral Res 168:36-50 The paradigm of protein acetylation in Parkinson's disease2019Yakhine-Diop SMS, Martínez-Chacón G, Uribe-Carretero E, Niso-Santano M, González-Polo RA, Fuentes JM.Neural Regen Res 14(6):975-976 Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson´s Disease Patients.2019Yakhine-Diop, S.M.S. Niso-Santano, M. Rodríguez-Arribas, M. Gómez-Sánchez, R. Martínez-Chacón, G. Uribe-Carretero, E. Navarro-García, J.A. Ruiz-Hurtado, G. Aiastui, A. Cooper, J.M. López de Munaín, A. Bravo-San Pedro, J.M. González-Polo, R.A. Fuentes, J.M. Mol Neurobiol. 56(4):2466-2481 Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity2019Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G.Cell Metab 30(4):754-767 Molecular characterization of autophagic and apoptotic signaling induced by Sorafenib in liver cancer cells.2018Rodríguez Hernández, M.A. González, R. De la Rosa, A.J. Gallego, P. Ordóñez, R. Navarro-Villarán, E. Contreras, L. Rodríguez-Arribas, M. González-Gallego, J. Álamo-Martínez, J.M. Marín-Gómez, L.M. Del Campo, J.A. Quiles, J.M. Fuentes, J.M. De la Cruz, J. Mauriz, J.L. Padillo, F.J. Muntané, J. J Cell Physiol 234(1):692-708 Acetylome in Human Fibroblasts from Parkinson´s Disease.2018Yakhine-Diop, S.M.S. Rodríguez-Arribas, M. Martínez-Chacón, G. Uribe-Carretero, E. Gómez-Sánchez, R. Aiastui, A. López de Munaín, A. Bravo-San Pedro, J.M. Niso-Santano, M. González-Polo, R.A. Fuentes, J.M. Front Cell Neurosci 12:97 ER-mitochondria signaling in Parkinson's disease.2018Gómez-Suaga P, Bravo-San Pedro JM, González-Polo RA, Fuentes JM, Niso-Santano M. Cell Death Dis. 9(3):337 Cholesterol and multilamellar bodies: Lysosomal dysfunction in GBA-Parkinson disease.2018García-Sanz P, Orgaz L, Fuentes JM, Vicario C, Moratalla R.Autophagy 14(4):717-718 Vascular Risk Factors and Lesions of Vascular Nature in Magnetic Resonance as Predictors of Progression to Dementia in Patients with Mild Cognitive Impairment2018Romero-Sevilla R, Casado-Naranjo I, Portilla-Cuenca JC, Duque-de San Juan B, Fuentes JM, Lopez-Espuela F.Curr Alzheimer Res 15(7):671-678 Detection and classification of chronic kidney disease in Primary Care and importance of albuminuria2018Labrador PJ, González-Sanchidrián S, Polanco S, Davin E, Fuentes JM, Gómez-Martino JR.Semergen 44(2):82-89 N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease2017García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, Kulisevsky J, Gutierrez A, Dávila JC, González-Polo RA, Fuentes JM, Mir P, Vicario C, Moratalla R.Mov Disord 32(10):1409-1422. Fluorescent FYVE Chimeras to Quantify PtdIns3P Synthesis During Autophagy 2017Yakhine-Diop, S.M.S. Martínez-Chacón, G. González-Polo, R.A. Fuentes, J.M. Niso-Santano, M.Methods Enzymol 587:257-269 Turnover of lipidated LC3 and autophagic cargoes in mammalian cells. 2017Rodríguez-Arribas, M. Yakhine-Diop, S.M.S. González-Polo, R.A. Niso-Santano, M. Fuentes, J.M. Methods Enzymol 587:55-70 Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease2017Rodríguez-Arribas M, Yakhine-Diop SMS, Pedro JMB, Gómez-Suaga P, Gómez-Sánchez R, Martínez-Chacón G, Fuentes JM, González-Polo RA, Niso-Santano M.Mol Neurobiol 54(8):6287-6303 Inhibitor of growth protein 4 interacts with Beclin 1 and represses autophagy2017Sica V, Bravo-San Pedro JM, Chen G, Mariño G, Lachkar S, Izzo V, Maiuri MC, Niso-Santano M, Kroemer G.Oncotarget 8(52):89527-89538 Mitochondria: Key Organelle in Parkinson's Disease2016Gómez-Sánchez R, Bravo-San Pedro JM, Gegg ME, González-Polo RA, Fuentes JM.Parkinsons Dis.2016:6230370. PINK1 deficiency enhances autophagy and mitophagy2016induction.Gómez-Sánchez R, Yakhine-Diop SM, Bravo-San Pedro JM, Pizarro-Estrella E, Rodríguez-Arribas M, Climent V, Martin-Cano FE, González-Soltero ME, Tandon A, Fuentes JM, González-Polo RA. Mol Cell Oncol 3(2):e1046579 mRNA and protein dataset of autophagy markers (LC3 and p62) in several cell lines2016Gómez-Sánchez R, Yakhine-Diop SM, Rodríguez-Arribas M, Bravo-San Pedro JM, Martínez-Chacón G, Uribe-Carretero E, Pinheiro de Castro DC, Pizarro-Estrella E, Fuentes JM, González-Polo RA.Data Brief. 7:641-7 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).2016Klionsky DJ.... Fuentes JM,.........González-Polo RA....Niso-Santano M... Zughaier SM. Autophagy 12(1):1-222. Association between subclinical carotid atherosclerosis, hyperhomocysteinaemia and mild cognitive impairment2016Casado-Naranjo I, Romero Sevilla R, Portilla Cuenca JC, Duque de San Juan B, Calle Escobar ML, Fernández Pereira L, Fuentes JM, Ramírez-Moreno JM.Acta Neurol Scand. 134(2):154-9. IFDOTMETER: A New Software Application for Automated Immunofluorescence Analysis2016Rodríguez-Arribas M, Pizarro-Estrella E, Gómez-Sánchez R, Yakhine-Diop SM, Gragera-Hidalgo A, Cristo A, Bravo-San Pedro JM, González-Polo RA, Fuentes JM.J Lab Autom.21(2):246-59. Pompe Disease and Autophagy: Partners in Crime, or Cause and Consequence?2016Rodríguez-Arribas M, Pedro JM, Gómez-Sánchez R, Yakhine-Diop SM, Martínez- Chacón G, Uribe-Carretero E, De Castro DC, Casado-Naranjo I, López de Munaín A, Niso-Santano M, Fuentes JM, González-Polo RA. Curr Med Chem. 23(21):2275-85. Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?2015 González-Polo RA, Pizarro-Estrella E, Yakhine-Diop SM, Rodríguez-Arribas M, Gómez-Sánchez R, Pedro JM, Fuentes JM. Curr Top Med Chem. 15(21):2152-74. Routine Western blot to check autophagic flux: cautions and recommendations.2015Gómez-Sánchez R, Pizarro-Estrella E, Yakhine-Diop SM, Rodríguez-Arribas M, Bravo-San Pedro JM, Fuentes JM, González-Polo RA.Anal Biochem. 477:13-20. Association of vascular factors and amnestic mild cognitive impairment: a comprehensive approach.2015Casado Naranjo I, Portilla Cuenca JC, Duque de San Juan B, García AF, Sevilla RR, Serrano Cabrera A, Hijón CC, Romero Chala S, Fuentes JM, Ramírez Moreno JM. J Alzheimers Dis. 44(2):695-704. G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy. 2014Yakhine-Diop SM, Bravo-San Pedro JM, Gómez-Sánchez R, Pizarro-Estrella E, Rodríguez-Arribas M, Climent V, Aiastui A, López de Munain A, Fuentes JM, González-Polo RA. Toxicology. 324:1-9. doi: Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.2014Gómez-Suaga P, Fdez E, Fernández B, Martínez-Salvador M, Blanca Ramírez M, Madero-Pérez J, Rivero-Ríos P, Fuentes JM, Hilfiker S. Neuropharmacology. 85:45-56. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. 2014Gómez-Sánchez R, Gegg ME, Bravo-San Pedro JM, Niso-Santano M, Alvarez-Erviti L, Pizarro-Estrella E, Gutiérrez-Martín Y, Alvarez-Barrientos A, Fuentes JM, González-Polo RA, Schapira AH. Neurobiol Dis. 62(100):426-40. Implication of autophagy in Parkinson's disease.2013González-Polo RA, Fuentes JM, Niso-Santano M, Alvarez-Erviti L. Parkinsons Dis. 2013:436481. Autophagy, mitochondria and 3-nitropropionic acid joined in the same model 2013González-Polo RA, Bravo-San Pedro JM, Gómez-Sánchez R, Pizarro-Estrella E, Niso-Santano M, Fuentes JM.Br J Pharmacol. 168(1):60-2. doi: The LRRK2 G2019 mutant exacerbates basal autophagy through activation of the MEK/ERK pathway 2013Bravo-San Pedro JM, Niso-Santano M, Gómez-Sánchez R, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Cell Mol Life Sci. 70(1):121-36. Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease.2012Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, González-Polo RA, Fuentes JM. Biochem Soc Trans. 40(5):1129-33. Guidelines for the use and interpretation of assays for monitoring autophagy.2012Klionsky DJ…..Fuentes JM..…González-Polo RA,…..Zuckerbraun B.Autophagy. 8(4):445-544. The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.2012Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Autophagy. 8(10):1537-9. Inhibition of autophagy by TAB2 and TAB32011Criollo A, Niso-Santano M, Malik SA, Michaud M, Morselli E, Mariño G, Lachkar S, Arkhipenko AV, Harper F, Pierron G, Rain JC, Ninomiya-Tsuji J, Fuentes JM, Lavandero S, Galluzzi L, Maiuri MC, Kroemer G. . EMBO J. 30(24):4908-20. Fipronil is a powerful uncoupler of oxidative phosphorylation that triggers apoptosis in human neuronal cell line SHSY5Y. 2011Vidau C. González-Polo, R.A. Niso-Santano, M. Gómez-Sánchez, R. Bravo-San Pedro, J.M. Pizarro-Estrella, E. Blasco, R. Brunet, J.L. Belzunces, L.P. Fuentes J.M. Neurotoxicology. 32(6):935-43. ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress2011Niso-Santano M, Bravo-San Pedro JM, Gómez-Sánchez R, Climent V, Soler G, Fuentes JM, González-Polo RA. Toxicol Sci. 119(1):156-68. Protective effect of the glial cell line-derived neurotrophic factor (GDNF) on human mesencephalic neuron-derived cells against neurotoxicity induced by paraquat2011Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Bonmatty RG, Fuentes JM.Environ Toxicol Pharmacol. 31(1):129-36. Nitric oxide in paraquat-mediated toxicity: A review. 2010Morán JM, Ortiz-Ortiz MA, Ruiz-Mesa LM, Fuentes JM. J Biochem Mol Toxicol. 24(6):402-9. DJ-1 as a modulator of autophagy: an hypothesis.2010González-Polo RA, Niso-Santano M, Gómez-Sánchez R, Bravo-San Pedro JM, Fuentes JM. ScientificWorldJournal 17;10:1574-9. The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells2010Gómez-Sánchez R, Bravo-San Pedro JM, Niso-Santano M, Soler G, Fuentes JM,González-Polo RA. Neurotoxicology 31(6):701-8. Paraquat exposure induces nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the activation of the nitric oxide-GAPDH-Siah cell death cascade.2010Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Bravo-San Pedro JM, Fuentes JM.Toxicol Sci. 116(2):614-22 Prevalencia de las mutaciones G2019S y R1441 de LRRK2 en pacientes con enfermedad de Parkinson en Extremadura, España [Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain]2010Morán JM, Castellanos-Pinedo F, Casado-Naranjo I, Durán-Herrera C, Ramírez-Moreno JM, Gómez M, Zurdo-Hernández JM, Fuentes E, Ortiz-Ortiz MA, Moreno AD, González-Polo RA, Niso-Santano M, Bravo-San Pedro JM, Pérez-Tur J, Ruiz-Mesa LM, Fuentes JM.Rev Neurol. 50(10):591-4. Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells.2010Morán JM, Ortiz-Ortiz MA, Ruiz-Mesa LM, Niso-Santano M, Bravo-San Pedro JM, Sánchez RG, González-Polo RA, Fuentes JM. Nitric Oxide. 23(1):51-9 Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.2010Niso-Santano M, González-Polo RA, Bravo-San Pedro JM, Gómez-Sánchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Morán JM, Cuadrado A, Fuentes JM Free Radic Biol Med. 48(10):1370-81 Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. 2010Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Niso-Santano M, Bravo-San Pedro JM, Gómez-Sánchez R, González-Polo RA, Fuentes JM. Neurosci Lett. 468(2):120-4 Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. 2009Ortiz-Ortiz MA, Morán JM, Bravo-San Pedro JM, González-Polo RA, Niso-Santano M, Anantharam V, Kanthasamy AG, Soler G, Fuentes JM.Neurotoxicology 30(6):1008-18 Nitric oxide-mediated toxicity in paraquat-exposed SH-SY5Y cells: a protective role of 7-nitroindazole.2009Ortiz-Ortiz MA, Morán JM, González-Polo RA, Niso-Santano M, Soler G, Bravo- San Pedro JM, Fuentes JM. Neurotox Res. 6(2):160-73 Silencing DJ-1 reveals its contribution in paraquat-induced autophagy.2009González-Polo R, Niso-Santano M, Morán JM, Ortiz-Ortiz MA, Bravo-San Pedro JM, Soler G, Fuentes JM. J Neurochem. 109(3):889-98 Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.2009Fitzpatrick JM, Fuentes JM, Chalmers IW, Wynn TA, Modolell M, Hoffmann KF, Hesse M. Int J Parasitol. 39(3):267-79 Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways.2008Moran JM, Gonzalez-Polo RA, Ortiz-Ortiz MA, Niso-Santano M, Soler G, Fuentes JM. J Toxicol Environ Health A. 71(22):1457-67 Age-related alteration of arginase activity impacts on severity of leishmaniasis.2008Müller I, Hailu A, Choi BS, Abebe T, Fuentes JM, Munder M, Modolell M, Kropf P. PLoS Negl Trop Dis. 2(5):e235. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.2008Klionsky DJ.... Fuentes JM.... Deter RL. Autophagy. 4(2):151-75. Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy.2007Kropf P, Baud D, Marshall SE, Munder M, Mosley A, Fuentes JM, Bangham CR, Taylor GP, Herath S, Choi BS, Soler G, Teoh T, Modolell M, Müller I. Eur J Immunol. 37(4):935-945. Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat: could autophagy be a "brake" in paraquat-induced apoptotic death?2007González-Polo RA, Niso-Santano M, Ortíz-Ortíz MA, Gómez-Martín A, Morán JM, García-Rubio L, Francisco-Morcillo J, Zaragoza C, Soler G, Fuentes JM. Autophagy; 3(4):366-7 Inhibition of Paraquat-Induced Autophagy Accelerates the Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells2007González-Polo RA, Niso-Santano M, Ortíz-Ortíz MA, Gómez-Martín A, Morán JM, García-Rubio L, Francisco-Morcillo J, Zaragoza C, Soler G, Fuentes JMToxicological Sciences 97(2) 448-458, Low Concentrations of Paraquat Induces Early Activation of Extracellular Signal-Regulated Kinase 1/2, Protein Kinase B, and c-Jun N-terminal Kinase 1/2 Pathways: Role of c-Jun N-Terminal Kinase in Paraquat-Induced Cell Death2006Niso-Santano M, Morán JM, García-Rubio L, Gómez-Martín A, González-Polo RA, Soler G, Fuentes JM. Toxicological Sciences 92(2) 507-515, Th1/Th2 cytokines: an easy model to study gene expression in immune cells.2006Morán, J.M. González-Polo, R.A. Soler, G. Fuentes, J.M. CBE Life Sci Educ 5(3):287-95. Suppression of T cell functions by human granulocyte arginase.2006Munder, M. Schneider, H. Luckner, C. Giese, T. Langhans, C.D. Fuentes, J.M. Kropf, P. Mueller, I. Kolb, A. Modolell, M. Ho, A.D. Blood 108(5):1627-34 Expression in yeast and purification of a membrane protein, SERCA1a, using a biotinylated acceptor domain 2006Jidenko, M. Lenoir, G. Fuentes, J.M. Maire, M.L. Jaxel, C. Protein Expr Purif 48(1):32-42 Heat shock proteins protect both MPP(+) and paraquat neurotoxicity. 2005Donaire, V. Niso-Santano, M. Morán, J.M. García, L. González-Polo, R.A. Soler, G. Fuentes JM. Brain Res Bull 67(6):509-14 Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. 2005Kropf, P. Fuentes, J.M. Fahnrich, E. Arpa, L. Herath, S. Weber, V. Soler, G. Celada, A. Modolell, M. Muller, I. FASEB J 19(8):1000-2 PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor 2005González-Polo, R.A. Carvalho, G. Braun, T. Decaudin, D. Fabre, C. Larochette, N. Perfettini, J.L. Djavaheri-Mergny, M. Youlyouz-Marfak, I. Codogno, P. Raphael, M. Feuillard, J. Kroemer, G.Oncogene 24(51):7503-13 The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.2005González-Polo, R.A. Boya, P. Pauleau, A.L. Jalil, A. Larochette, N. Souquere, S. Eskelinen, E.L. Pierron, G. Saftig, P. Kroemer, G. J Cell Sci 118(Pt 14):3091-102 Inhibition of macroautophagy triggers apoptosis. 2005Boya, P. González-Polo, R.A. Casares, N. Perfettini, J.L. Dessen, P. Larochette, N. Metivier, D. Meley, D. Souquere, S. Yoshimori, T. Pierron, G. Codogno, P. Kroemer, G. Mol Cell Biol 25(3):1025-40 Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.2005Munder, M. Mollinedo, F. Calafat, J. Canchado, J. Gil-Lamaignere, C. Fuentes, J.M. Luckner, C. Doschko, G. Soler, G. Eichmann, K. Muller, F.M. Ho, A.D. Goerner, M. Modolell, M. Blood 105(6):2549-56 MPP+: mechanism for its toxicity in cerebellar granule cells.2004González-Polo, R.A. Soler, G. Fuentes, J.M. Mol Neurobiol 30(3):253-64 Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants.2004González-Polo, R.A. Soler, G. Rodríguez-Martín, A. Morán, J.M. Fuentes, J.M. Cell Biol Int 28(5):373-80. Paraquat-induced apoptotic cell death in cerebellar granule cells.2004González-Polo, R.A. Rodríguez-Martín, A. Morán, J.M. Niso-Santano, M. Soler, G. Fuentes, J.M. Brain Res 1011(2):170-6. Viral proteins targeting mitochondria: controlling cell death 2004Boya, P. Pauleau, A.L. Poncet, D. González-Polo, R.A. Zamzami, N. Kroemer, G.Biochim Biophys Acta 1659(2-3):178-89 Involvement of the cytoplasmic loop L6-7 in the entry mechanism for transport of Ca2+ through the sarcoplasmic reticulum Ca2+-ATPase. 2003Corre, F. Jaxel, C. Fuentes, J.M. Menguy, T. Falson, P. Levine, B.A. Moller, J.V. le Maire, M. Ann N Y Acad Sci 986:90-5 MPP(+) causes inhibition of cellular energy supply in cerebellar granule cells.2003González-Polo, R.A. Soler, G. Alonso, J.C. Rodríguez-Martín, A. Fuentes, J.M. Neurotoxicology 24(2):219-25 Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells. 2003González-Polo, R.A. Soler, G. Alvarez, A. Fabregat, I. Fuentes, J.M. J Neurochem 84(2):305-15 The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family. 2003Boya, P. Morales, M.C. González-Polo, R.A. Andreau, K. Gourdier, I. Perfettini, J.L. Larochette, N. Deniaud, A. Baran-Marszak, F. Fagard, R. Feuillard, J. Asumendi, A. Raphael, M. Pau, B. Brenner, C. Kroemer, G. Oncogene 22(40):6220-30 Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine 2003Boya, P. González-Polo, R.A. Poncet, D. Andreau, K. Vieira, H.L. Roumier, T. Perfettini, J.L. Kroemer, G.Oncogene;22(25):3927-36 Mitochondrion-targeted apoptosis regulators of viral origin. 2003Boya, P. Roumier, T. Andreau, K. González-Polo, R.A. Zamzami, N. Castedo, M. Kroemer, G. Biochem Biophys Res Commun 304(3):575-81. Diagnostic performance of arginase activity in colorectal cancer.2002del Ara, R.M. González-Polo, R.A. Caro, A. del Amo, E. Palomo, L. Hernandez, E. Soler, G. Fuentes, J.M. Clin Exp Med 2(1):53-7. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. 2001Hesse, M. Modolell, M. La Flamme, A.C. Schito, M. Fuentes, J.M. Cheever, A.W. Pearce, E.J. Wynn, T.A. J Immunol 167(11):6533-44 Mechanisms of MPP(+) incorporation into cerebellar granule cells 2001González-Polo, R.A. Mora, A. Clemente, N. Sabio, G. Centeno, F. Soler, G. Fuentes, J.M.Brain Res Bull 56(2):119-23 Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al. 2000Fuentes JM, Lompré AM, Møller JV, Falson P, le Maire M. Anal Biochem. 285(2):276-8 Implications of the S-shaped domain in the quaternary structure of human arginase 2000Mora A, del Ara Rangel M, Fuentes JM, Soler G, Centeno F.Biochim Biophys Acta. 1476(2):181-90. Different mechanisms of protection against apoptosis by valproate and Li+.1999Mora A, González-Polo RA, Fuentes JM, Soler G, Centeno F. Eur J Biochem. 266(3):886-91. Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons.Centeno F, 1998Mora A, Fuentes JM, Soler G, Claro E. Neuroreport. 9(18):4199-203. Kinetics and inhibition by some aminoacids of lactating rat mammary gland arginase 1994Fuentes JM, Campo ML, Soler G.Arch Int Physiol Biochim Biophys. 102(5):255-8. Oscillations in rat liver cytosolic enzyme activities of the urea cycle. 1994Fuentes JM, Pascual MR, Salido G, Soler G, Madrid JA. Arch Int Physiol Biochim Biophys. 102(5):237-41. Immunological identity of the two different molecular mass constitutive subunits of liver arginase.1994Diez A, Fuentes JM, Prada F, Campo ML, Soler G. Biol Chem Hoppe Seyler (8):537-41. Kinetics of manganese reconstitution and thiol group exposition in dialyzed rat mammary gland arginase.1994Fuentes JM, Campo ML, Soler G. Int J Biochem. 26(5):653-9. Parallel induction of nitric oxide and glucose-6-phosphate dehydrogenase in activated bone marrow derived macrophages. 1993Corraliza IM, Campo ML, Fuentes JM, Campos-Portuguez S, Soler G. Biochem Biophys Res Commun. 196(1):342-7. Unfolding and trypsin inactivation studies reveal a conformation drift of glucose-6-phosphate dehydrogenase upon binding of NADP.1992Bautista JM, Fuentes JM, Diez A, Gutiérrez-Merino C, Soler G. Biochim Biophys Acta. 1122(1):99-106. An arginine regulated gamma-guanidobutyrate ureahydrolase from tench liver (Tinca tinca L.). 1992Campo ML, Fuentes JM, Soler G. Arch Int Physiol Biochim Biophys. 100(1):55-60. Physico-chemical properties of hepatocyte plasma-membrane-bound arginase.1991Fuentes JM, Campo ML, Soler G. Arch Int Physiol Biochim Biophys. 99(6):413-7. 
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